The critical-to-quality (CTQ) attributes for heparosan applications include composition of heparosan, absence of any unnatural moieties, and heparosan molecular weight size and unimodal distribution. Probiotic bacteria E. coli Nissle 1917 (EcN) is a natural producer of heparosan.
An engineered probiotic designed to treat a metabolic disease enters clinical trials. E. coli Nissle 1917 has been tested in animal experiments for the treatment of inflammatory bowel disease
Escherichia coli Nissle 1917 (EcN) is a Gram‐negative probiotic, originally isolated by Dr. Alfred Nissle during World War I (Nissle, 1918; Nissle, 1925 ). EcN is serum‐sensitive and does not produce any enterotoxins or cytotoxins associated with pathogenic E. coli strains (Sonnenborn and Schulze, 2009 ).
Increased numbers of adherent invasive Escherichia coli (AIEC) have been found in Crohn's disease (CD) patients. In this report, we investigate the potential of the probiotic Escherichia coli Nissle 1917 (EcN) to reduce features associated with AIEC pathogenicity in an already established infection …
The non-genotoxic E. coli Nissle 1917 mutant exacerbates the mortality of colitic mice. We next examined the probiotic properties of the non-genotoxic E. coli Nissle 1917 mutant in a T-cell dependent model of chronic colitis induced by the adoptive transfer of naïve CD4 + CD45RB high T cells in immunocompromised SCID
We therefore analyzed the effects of msbB deletion on the growth of E. coli Nissle 1917 (K-5 capsule) in LB medium supplemented with different compounds and also investigated whether the protein expression pattern of the bacteria was changed. In Figure 2A the growth of wild-type E. coli Nissle 1917 and its msbB-mutant in LB medium was analyzed
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e coli nissle 1917 probiotic
